Serum Enzyme Activity in Muscular Dystrophy
نویسندگان
چکیده
منابع مشابه
Serum Enzyme Profiles Differentiate Five Types of Muscular Dystrophy
BACKGROUND Differentiation among types of muscular dystrophy (MD) has remained challenging. In this retrospective study, we sought to develop a methodology for differentiation of MD types using analysis of serum enzyme profiles. METHODS The serum levels of enzymes from 232 patients, including 120 with DMD, 36 with BMD, 36 with FSHD, 46 with LGMD, and 11 with EDMD, were evaluated. RESULTS Th...
متن کاملSerum Creatinine Level: A Supplemental Index to Distinguish Duchenne Muscular Dystrophy from Becker Muscular Dystrophy
BACKGROUND To improve assessment of dystrophinopathy, the aim of this study was to identify whether serum creatinine (Crn) level reflects disease severity. METHODS Biochemical, Vignos score, and genetic data were collected on 212 boys with dystrophinopathy. RESULTS Serum Crn level had a strong inverse correlation with Vignos score by simple correlation (r = -0.793) and partial correlation a...
متن کاملP164: Adeno-Associated Viral Vectors in Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...
متن کاملSerum Enzyme Studies in Muscle Disease. Ii. Serum Creatine Kinase Activity in Muscular Dystrophy and in Other Myopathic and Neuropathic Disorders.
It has been established that the levels of certain enzymes are elevated in the serum of patients suffering from muscular dystrophy. Previous studies (Pearson, 1957; Dreyfus, Schapira, and Demos, 1958; Thompson and Vignos, 1959; Schapira, Dreyfus, Schapira, and Demos, 1960; Thomson, Leyburn, and Walton, 1960; Pearson, Chowdhury, Fowler, Jones, and Griffith, 1961) have indicated that a number of ...
متن کاملMatrix metalloproteinases in serum of Emery-Dreifuss muscular dystrophy patients.
In the pathogenesis of dilated cardiomyopathy (DCM) in Emery-Dreifuss muscular dystrophy (EDMD) matrix metalloproteinases (MMPs) are supposed to be involved and may have diagnostic/prognostic value. Serum levels of MT1-MMP, MMP-2 and MMP-9 were quantified by ELISA and zymography in 22 EDMD patients and 15 age-matched controls. In the autosomal-dominant EDMD MMP-2 and MT1-MMP were increased in a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1960
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5208.1276